Endocrine Abstracts

Prevalence of Paget’s disease (PD) of bone as well as clinical and demographical presentation may differ between the populations.Aim: In this study we evaluate clinical and demographical parameters of Paget’s disease patients followed from endocrinology clinics in Turkey.Method: An invitation was sent to all tertiary endocrinology clinics to complete a survey on demographic clinical, laboratory parameters, treatment modal...

Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease.Methods: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Pa...

Introduction: Insulinoma is a rare neuroendocrine tumor. 90% of insulinoma is solitaire and benign, and 10% is malignant. Although seen at any age, it is most commonly noticed in 4th and 6th decades.Case: A 78-year-old man was referred to a neurology clinic upon a sudden faint, disability to remember and meaningless behavior, and diagnosed with epilepsy in 2008. In 2012, he had a hypoglycemia attack (blood glucose 30 mg/dl) and was referred to Ege Univer...

Background: We investigated the demographic and clinical features of patients with Hashimoto’s thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey.Methods: Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Patients with Hashi...

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...

Introduction: Pseudohypoparathyroidism (PHP) is a rare disease characterized by end-organ resistance to parathyroid hormone, causing hypocalcemia with hyperphosphatemia and elevated parathormone (PTH) levels. A prevalence of 3.4/million has been reported. Here, we present a rare case with PHP.Case report: A 28-year-old male patient with spasms in hands and feet was evaluated in the outpatient department of neurology and was referred to endocrinology clin...

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is also known as autoimmune polyendocrine syndrome type 1 (APS-1). We present a case of autoimmune polyendocrine syndrome type 1 with hypercalcaemia of adrenal insufficiency during the calcium treatment because of hypoparathyroidism.Case: A 20-year-old female patient was diagnosed with APS-1 in 2004. She applied to ER with the complaints of nausea and vomiting. Her laboratory finding...

Medullar thyroid cancer (MTK) approximately constitutes 5% of thyroid cancer, over the 25% cases it progresses in familial form. In charge of genetic inherited clinical features in RET protooncogene ‘germ-line’ makes up activating mutations. In post RET mutation in association with tyrosine kinase activation oncogenic cell proliferation is increased. In medullary thyroid cancer persistent and recurrence disease management is complicated, because it is unresponsive to...

Introduction: Dyskeratosis congenita is a rare multisystemic disease characterised with atrophy on skin, pigmentation, nail dystrophy, leukoplakia in mucous membrane, bone marrow failure, and tendency to malignancy. We present a rare case of dyskeratosis congenita associated with hypothyroidism and hypogonadism.Case: A 30-year-old male patient was referred to Endocrinology Department with the findings of micropenis and atrophic testicles. His parents had...